Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.
CITATION STYLE
Cociancich, S., Pesic, A., Petras, D., Uhlmann, S., Kretz, J., Schubert, V., … Süssmuth, R. D. (2015). The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine. Nature Chemical Biology, 11(3), 195–197. https://doi.org/10.1038/nchembio.1734
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