Skip to content

Host innate immune response to Mycobacterium tuberculosis

by K Bhatt, P Salgame
J Clin Immunol ()
Get full text at journal

Abstract

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

Cite this document (BETA)

Readership Statistics

5 Readers on Mendeley
by Discipline
 
100% Agricultural and Biological Sciences
by Academic Status
 
40% Student > Ph. D. Student
 
20% Professor > Associate Professor
 
20% Student > Doctoral Student

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in