This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-γ-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease. © 2007 Springer Science+Business Media, LLC.
CITATION STYLE
Bhatt, K., & Salgame, P. (2007, July). Host innate immune response to Mycobacterium tuberculosis. Journal of Clinical Immunology. https://doi.org/10.1007/s10875-007-9084-0
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