N(Boc)-L-(2-Bromoallyl)-glycine (1) was synthesized from diethylacetamidomalonate and 2,3-dibromopropene in a one-pot procedure (75 % overall yield). The enantiomers were efficiently separated via a tandem biocatalytic kinetic hydrolytic resolution. 1 was elaborated to several other interesting unnatural amino acid. © 1993.
CITATION STYLE
Leanna, M. R., & Morton, H. E. (1993). N-(Boc)-L-(2-Bromoallyl)-glycine: A versatile intermediate for the synthesis of optically active unnatural amino acids. Tetrahedron Letters, 34(28), 4485–4488. https://doi.org/10.1016/0040-4039(93)88065-Q
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