Motivation: Early and accurate detection of human pathogen infection is critical for treatment and therapeutics. Here we describe pathogen identification using short RNA subtraction and assembly (SRSA), a detection method that overcomes the requirement of prior knowledge and culturing of pathogens, by using degraded small RNA and deep sequencing technology. We prove our approach's efficiency through identification of a combined viral and bacterial infection in human cells. © The Author(s) 2011. Published by Oxford University Press.
CITATION STYLE
Isakov, O., Modai, S., & Shomron, N. (2011). Pathogen detection using short-RNA deep sequencing subtraction and assembly. Bioinformatics, 27(15), 2027–2030. https://doi.org/10.1093/bioinformatics/btr349
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