Prematurity, intrauterine growth retardation and low birth weight: Risk factors in a malaria-endemic area in Southern Benin

Abstract

Background: The aim of this study was to describe the contribution of prematurity and small for gestational age (SGA) to low birth weight (LBW) as well as to identify risk factors associated with preterm birth and SGA and to explore their impact on birth weight. Methods: A cross-sectional study was carried out in southern Benin between June 2007 and July 2008. At delivery, women's characteristics and newborn's anthropometric measurements were collected. Gestational agewas estimated using the Ballard method; SGA was defined using the William's reference curve. Analyses were performed by multiple logistic and linear regressions. Results: In total, 526 mother-infant pairs were enrolled. LBW (<2500 g), prematurity (<37 weeks) and SGA accounted for 9.1%, 10.3% and 25.3% of the sample, respectively. Infant's male gender was associated with a lower risk of prematurity (p=0.03). Low maternal anthropometric status (p<0.001), primiparity (p=0.017) and infant's male gender (p=0.015) were associated with an increased risk of SGA. Only low maternal anthropometric status and primiparity were associated with an increased risk of LBW, and their effect on LBW was mediated by SGA. Conclusions: SGAwas the main mechanism mediating the effect of risk factors on LBW. Maternal undernutrition (either short stature or low anthropometric status) was the most important of them. © The Author 2013. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved.