Abstract
Retroactivity is a phenomenon that changes the desired input/output response of a system when it is connected to "downstream" systems. Transcriptional networks are not immune to this phenomenon. In this paper, we propose a phosphorylation-based design for a bio-molecular system that acts as an insulator between its upstream systems and its downstream ones in a transcriptional network. Performing singular perturbation analysis, we mathematically show that such a design attenuates retroactivity. Stochastic simulations are run to analyze the robustness of the proposed device to biological noise and to highlight design tradeoffs. © 2008 IEEE.
Cite
CITATION STYLE
Del Vecchio, D., & Jayanthi, S. (2008). Retroactivity attenuation in transcriptional networks: Design and analysis of an insulation device. In Proceedings of the IEEE Conference on Decision and Control (pp. 774–780). Institute of Electrical and Electronics Engineers Inc. https://doi.org/10.1109/CDC.2008.4739037
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