In Silico Molecular Interaction Studies of Suberoylanilide Hydroxamic Acid and Its Modified Compounds with Histones Deacetylase Class II Homo sapiens as Curative Measure towards Cervical Cancer

Abstract

The threat of cervical cancer is a serious problem forthe women’s health. It is already known that the cause of cervical cancer isdefinitely HPV (Human Papilloma Virus).The drug development is the most reasonable approach for coping with HPVinfection. The development of HDACi (Histone Deacetylase inhibitor) is seen asa feasible method for curing the threat of cervical cancer. Rational drugdesign is our utilized pipeline for drug development. The LigX MOE-based methodhas been developed to investigate the molecular interaction of HDAC class IIHomo sapienswith the designed leadcompound. The method has found that ligands 1c, 2a,and 2c are indeed feasible tobe formulated as drug candidates.