The flavonoid fraction of Tephrosia purpurea (FFTP) was studied for its effect on cellular and humoral functions and on macrophage phagocytosis in mice. Oral administration of FFTP (10-40 mg/kg) significantly inhibited sheep red blood cells (SRBC)-induced delayed-type hypersensitivity reactions. It also produced a significant, dose-related decrease in sheep erythrocyte-specific haemagglutination antibody titre. However, the fraction failed to show a significant change in the macrophage phagocytic activity. The results obtained indicate the ability of the flavonoidal fraction of T. purpurea to modulate both the cell-mediated and the humoral components of the immune system. © 2003 Elsevier Science B.V. All rights reserved.
CITATION STYLE
Damre, A. S., Gokhale, A. B., Phadke, A. S., Kulkarni, K. R., & Saraf, M. N. (2003). Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea. Fitoterapia, 74(3), 257–261. https://doi.org/10.1016/S0367-326X(03)00042-X
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