Validation of optical low coherence reflectometry retinal and choroidal biometry

Abstract

Purpose. To compare measurements of retinal thickness (RT) and choroidal thickness (ChT) obtained with an optical low coherence reflectometry (OLCR) biometer (Lenstar LS 900) with those obtained with a spectral domain optical coherence tomographer (SD OCT) (Copernicus SOCT HR) in young normal subjects. Methods. Twenty young adult subjects had foveal RT and subfoveal ChT measurements obtained with OLCR biometry and SD OCT. RT and ChT was derived through manual analysis of A-scan data from the OLCR biometer. An average SD OCT foveal B-scan image derived from a series of 50 multiple B-scans was also analyzed to determine RT and ChT for each subject. Measurements from the two instruments were compared using Pearson correlation and Bland-Altman analysis. Results. RT and ChT measurements from the two instruments were highly correlated (r2 of 0.80 and 0.94, respectively, p < 0.0001). The mean RT with SD OCT and OLCR were 195 ± 17 μm and 196 ± 16 μm, respectively (mean difference, 1 ± 8 μm). The mean ChT was 324 ± 71 μm and 328 ± 84 μm with SD OCT and OLCR, respectively (mean difference, 4 ± 24 μm). Conclusions. Foveal RT and subfoveal ChT measures from OLCR biometry exhibit a strong correlation and good agreement with measures derived from SD OCT in a population of young adult subjects. Copyright © 2011 American Academy of Optometry.