DNA methylation is a key mechanism of epigenetic regulation that is frequently altered in diseases such as cancer. To confirm the biological or clinical relevance of such changes, gene-specific DNA methylation changes need to be validated in multiple samples. We have developed the MethMarker http://methmarker.mpi-inf.mpg.de/ software to help design robust and cost-efficient DNA methylation assays for six widely used methods. Furthermore, MethMarker implements a bioinformatic workflow for transforming disease-specific differentially methylated genomic regions into robust clinical biomarkers.© 2009 Schüffler et al.; licensee BioMed Central Ltd.
CITATION STYLE
Schüffler, P., Mikeska, T., Waha, A., Lengauer, T., & Bock, C. (2009). MethMarker: User-friendly design and optimization of gene-specific DNA methylation assays. Genome Biology, 10(10). https://doi.org/10.1186/gb-2009-10-10-r105
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