Is there potential for repurposing statins as novel antimicrobials?

81Citations
Citations of this article
117Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Statins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulation, and antimicrobial effects. An increasing number of studies are emerging which detail the attenuation of bacterial growth and in vitro and in vivo virulence by statin treatment. In this review, we describe the current information available concerning the effects of statins on bacterial infections and provide insight regarding the potential use of these compounds as antimicrobial therapeutic agents.

Cite

CITATION STYLE

APA

Hennessy, E., Adams, C., Reen, F. J., & O’Gara, F. (2016, September 1). Is there potential for repurposing statins as novel antimicrobials? Antimicrobial Agents and Chemotherapy. American Society for Microbiology. https://doi.org/10.1128/AAC.00192-16

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free