IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate. © 2011 by Korean Society of Otorhinolaryngology-Head and Neck Surgery.
CITATION STYLE
Cho, H. K., Lee, Y. J., Chung, J. H., & Koo, J. W. (2011). Otologic manifestation in IgG4-related systemic disease. Clinical and Experimental Otorhinolaryngology, 4(1), 52–54. https://doi.org/10.3342/ceo.2011.4.1.52
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