Monitoring of paternal mitochondrial degradation in Caenorhabditis elegans

Abstract

In Caenorhabditis elegans embryos, paternally inherited mitochondria and their mitochondrial DNA are degraded via selective autophagy called allophagy (allogeneic organelle autophagy). This is a developmentally programmed autophagy and combined with C. elegans genetics and in vivo imaging provides a unique opportunity to analyze selective autophagy under physiological conditions.