HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at the antigen and allele levels, the repertoires of antibody-verified HLA epitopes, the use of HLAMatchmaker in determining the specificities of antibodies tested in different assays,and, finally, possible strategies to control HLA antibody responses.
CITATION STYLE
Duquesnoy, R. J. (2016, November 28). Reflections on HLA epitope-based matching for transplantation. Frontiers in Immunology. Frontiers Research Foundation. https://doi.org/10.3389/fimmu.2016.00469
Mendeley helps you to discover research relevant for your work.