The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans

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Abstract

Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy. Cryptococcus neoformans (C. neoformans) is a fungal pathogen that causes about 220,000 deaths annually in immunocompromised individuals. Munshi et al. explore fungal lipid metabolism in the context of C. neoformans pathogenicity.

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Munshi, M. A., Gardin, J. M., Singh, A., Luberto, C., Rieger, R., Bouklas, T., … Del Poeta, M. (2018). The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans. Cell Reports, 22(6), 1392–1400. https://doi.org/10.1016/j.celrep.2018.01.035

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