Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old African-American female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis. After failing conventional treatment regimens, the patient received a trial of ixekizumab with complete resolution of cutaneous lesions reported after 4 months and only 8 doses of the anti-IL-17 biologic agent.
Ghoneim, S., Ramos-Rodriguez, A. J., Vazquez de Lara, F., & Bonomo, L. (2017). The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab. Case Reports in Dermatological Medicine, 2017, 1–5. https://doi.org/10.1155/2017/3280215