New 3,4-seco ent-kaurenes from Croton caracasana flowers

Abstract

Two new 3,4-seco-ent-kaurenes, caracasine (1) and caracasine acid (2), were isolated from non-polar extracts of the flowers of Croton caracasana (Euphorbiaceae), together with six known terpenes, stigmasterol (4), stigmastenone (5), 2,6-dimethylocta-3,7-diene-2, 6-diol (6), spathulenol (7), caryophyllene oxide (8), and aromadendrene (9), and the flavonoid tribuloside (10). The chemical structures were determined by spectroscopic means and chemical correlations. All isolated compounds are being described for the first time for this species.