P12.24 The presence of atypia and positivity of the progesterone receptor as predictive factors of recurrence in grade I (WHO) meningiomas

Abstract

OBJECTIVE: Regarding to World Health Organization (WHO), grade I meningioma have an indolent behavior and reduced rate of recurrence. However, they may be more aggressive in the presence of atypical features. It is intended to determine the predictive factors of recurrence in grade I (WHO) meningiomas and reinforcing surveillance in patients at risk of recurrence / disease progression. METHOD: Review of clinical trials from 2007 to 2014, including. Information regarding age, gender, tumor location, degree of resection (Simpson), histology, immunohistochemistry, follow-up with objectivation of cases of recurrence and treatment time until relapse were obtained. Cases and not cases were related to the parameters measured in the first surgery. RESULTS: Were operated 579 patients with histological diagnosis of grade I meningioma, 428 of whom were female. Mean follow-up was 45.2 months, with 101 cases of recurrence. Of these, only 9 had undergone Simpson I resection. Of the 579 patients operated on, 196 had histological atypia, with a recurrence rate of 29.1%, compared with 11.5% who did not present atypia. In those who had progesterone positive receptors there was a recurrence of 23% and, 13.8% in those who did not present this positive. There was no relation between relapse and Ki67 values> 3.2%. CONCLUSION: Simpson I resection is the most effective measure in the control of the disease. In Simpson II-V resections, it will be useful to consider the presence of progesterone receptor positivity and atypia, in order to promote regular follow-up and increase patients survival and quality of life.