Protein binding and orientation matter: Bias-induced conductance switching in a mutated azurin junction

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Abstract

We observe reversible, bias-induced switching of conductance via a blue copper protein azurin mutant, N42C Az, with a nearly 10-fold increase at |V| > 0.8 V than at lower bias. No such switching is found for wild-type azurin, WT Az, up to |1.2 V|, beyond which irreversible changes occur. The N42C Az mutant will, when positioned between electrodes in a solid-state Au-protein-Au junction, have an orientation opposite that of WT Az with respect to the electrodes. Current(s) via both proteins are temperature-independent, consistent with quantum mechanical tunneling as dominant transport mechanism. No noticeable difference is resolved between the two proteins in conductance and inelastic electron tunneling spectra at

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Fereiro, J. A., Bendikov, T., Pecht, I., Sheves, M., & Cahen, D. (2020). Protein binding and orientation matter: Bias-induced conductance switching in a mutated azurin junction. Journal of the American Chemical Society, 142(45), 19217–19225. https://doi.org/10.1021/jacs.0c08836

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