In the present work, some new 5-Hydroxyindole 3-thiosemicarbazone 2-ones and 5-[2(3)-dialkylaminoalkoxy] Indole 3-hydrazone 2-ones were prepared from 5-hydroxy isatin. The structures of the products were characterized by IR, NMR, and MASS Spectral studies. All the compounds were examined for antioxidant activity by using 1,1-diphenyl-2-picryl-hydrazyl and hydrogen peroxide (H2O2), and the total antioxidant capacity by a phosphomolybdenum assay. In general, the derivatives were found to exhibit antioxidant activity. Further, the compounds with dialkyl amino alkoxy at the C5 position demonstrated significant antioxidant activity.
CITATION STYLE
Swathi, K., & Sarangapani, M. (2015). Synthesis and screening of biologically significant 5-Hydroxy isatin derivatives for antioxidant activity. Advances in Experimental Medicine and Biology, 822, 129–137. https://doi.org/10.1007/978-3-319-08927-0_14
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