Retrospective analysis of the predictive effect of coagulogram on the prognosis of intracerebral hemorrhage

Abstract

Objective: To determine the effective index of coagulogram after acute intracerebral hemorrhage (ICH) for predicting the outcome of ICH. Methods: A total of 641 patients with ICH were divided into two groups: the effective treatment group (healing well and improving) and ineffective treatment group (non-improving and dying). The coagulogram results of the two groups were analyzed with SPSS software 13.0, including PT, APTT, TT, and Fbg. The differences in these parameters were found by independent samples T test and Kruskal-Wallis test between the two groups. Then, the different parameters were obtained by logistic regression, which were significantly associated with the prognosis of acute cerebral hemorrhage patients. In addition, the odds ratio for the special indicators was calculated by chi-square test. Results: Only PT had a significant difference between the groups (p < 0.05) among the four parameters. The binary logistic regression analysis indicated that PT (p = 0.003) and APTT (p = 0.043) were related to the outcome of ICH patients. According to the chi-square test, the OR (odds ratio) of prolonged PT is 2.40 (1.34-4.29 with 95% CI) and that of prolonged APTT is 1.57 (1.01-2.42 with 95% CI). Conclusion: Prolonged PT and APTT are risk factors affecting the prognosis of ICH patients. Monitoring and controlling PT and APTT are advisable for improving the prognosis of ICH patients. © 2011 Springer-Verlag/Wien.