Effect Of Curcuma Xanthorrhiza Roxb. Extract on TNF α concentration and depression's score in patient with systemic lupus erythematosus

Abstract

Systemic Lupus Erythemathosus is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin's potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as the treatment group and 4 as a control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in the treatment group was significantly lower than before (p < 0.001) but the BDI score were not significantly lower than before (p=0.059). The TNF α concentration and BDI score showed a positive correlation, p = 0.024. This study demonstrates that Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and reduce clinically symptoms of depression in SLE patients.