Ventilation and Locomotion in Humans: Mechanisms, Implications, and Perturbations to the Coupling of These Two Rhythms

Abstract

To best sustain endurance activity, two systems must be effectively coordinated: ventilation and locomotion. Evidence has long suggested that these two mammalian rhythms are linked, yet determinants and implications of locomotor–respiratory coupling (LRC) continue to be investigated. Two general areas explaining the potential mechanisms underlying LRC are (1) neural interactions between central and peripheral controllers of locomotion and respiration, and (2) mechanical interactions between locomotor dynamics and respiratory mechanics. Additional suggested explanations for/consequence of the existence of LRC in mammals include an improved energetic cost of locomotion and a reduced sensation of breathlessness. As such, any perturbation to LRC, via alterations in breathing or kinematic patterns, could have negative performance implications to both athlete and patient populations