Abstract
Neurosteroids are steroids that are produced locally within the central nervous system independently of adrenal glands and gonads. Enzymes involved in neurosteroid biosynthesis are expressed in the cerebellum. These agents modulate the development of cerebellar neurons as well as glial cells. Neurosteroids exert neuroprotective actions and modulate synaptic transmission and plasticity in mature neurons. Defi cits in cerebellar neurosteroid production may play a role in the pathophysiology of neuropsychiatric disorders.
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Valenzuela, C. F. (2016). Neurosteroids. In Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students (pp. 273–277). Springer International Publishing. https://doi.org/10.1007/978-3-319-24551-5_36
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