A rare case of localized IgG4-related sclerosing cholecystitis mimicking gallbladder cancer

  • Ichinokawa M
  • Matsumoto J
  • Kuraya T
  • et al.
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Abstract

Objective: IgG4-related sclerosing cholecystitis is generally associated with IgG4-related sclerosing cholangitis and presents with diffuse, circumferential thickening of the gallbladder wall. We report a rare case of localized IgG4-related sclerosing cholecystitis without IgG4-related sclerosing cholangitis, which was difficult to differentiate from gallbladder cancer preoperatively. Patient: A 56-year-old man with suspected IgG4-related disease or gallbladder cancer was admitted to our ward. The serum IgG4 level was elevated at 721 mg/dL. Computed tomography (CT) demonstrated focal wall thickening of the gallbladder fundus. Drip infusion cholecystocholangiography with CT revealed no dilation, stenosis, or border irregularity of the bile duct. Results: For diagnostic and treatment purposes, cholecystectomy with wedge resection of the gallbladder bed was performed. The pathological diagnosis was IgG4-related sclerosing cholecystitis. Conclusion: It is difficult to differentiate IgG4-related sclerosing cholecystitis from gallbladder cancer in cases involving localized thickening of the gallbladder wall. In similar cases, surgical resec-tion with cancer in mind might be performed based on present clinical knowledge.

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APA

Ichinokawa, M., Matsumoto, J., Kuraya, T., Kuwabara, S., Wada, H., Kato, K., … Ono, K. (2019). A rare case of localized IgG4-related sclerosing cholecystitis mimicking gallbladder cancer. Journal of Rural Medicine, 14(1), 138–142. https://doi.org/10.2185/jrm.2998

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