Cryptosporidial infection suppresses intestinal epithelial cell mapk signaling impairing host anti-parasitic defense

9Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against Cryptosporidium infection. To counteract host defense response, Cryptosporidium has developed strategies of immune evasion to promote parasitic replication and survival within epithelial cells, but the underlying mechanisms are largely unclear. Using various models of intestinal cryptosporidiosis, we found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase (MAPK) signaling in infected murine intestinal epithelial cells. Whereas expression levels of most genes encoding the key components of the MAPK signaling pathway were not changed in infected intestinal epithelial cells, we detected a significant downregulation of p38/Mapk, MAP kinase-activated protein kinase 2 (Mk2), and Mk3 genes in infected host cells. Suppression of MAPK signaling was associated with an impaired intestinal epithelial defense against C. parvum infection. Our data suggest that cryptosporidial infection may suppress intestinal epithelial cell MAPK signaling associated with the evasion of host antimicrobial defense.

References Powered by Scopus

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): A prospective, case-control study

2777Citations
N/AReaders
Get full text

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2343Citations
N/AReaders
Get full text

Intestinal epithelial cells: Regulators of barrier function and immune homeostasis

2287Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Cryptosporidium parvum downregulates miR-181d in HCT-8 cells via the p50-dependent TLRs/NF-κB pathway

11Citations
N/AReaders
Get full text

Genomic Analysis of Gastrointestinal Parasite Resistance in Akkaraman Sheep

10Citations
N/AReaders
Get full text

Liposome-based nanocarriers loaded with anthrax lethal factor and armed with anti-CD19 VHH for effectively inhibiting MAPK pathway in B cells

10Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

He, W., Li, J., Gong, A. Y., Deng, S., Li, M., Wang, Y., … Chen, X. M. (2021). Cryptosporidial infection suppresses intestinal epithelial cell mapk signaling impairing host anti-parasitic defense. Microorganisms, 9(1), 1–12. https://doi.org/10.3390/microorganisms9010151

Readers over time

‘21‘22‘23‘2401234

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

50%

Researcher 3

50%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 1

25%

Medicine and Dentistry 1

25%

Veterinary Science and Veterinary Medic... 1

25%

Immunology and Microbiology 1

25%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0