Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially renders their insertion into genes phenotypically neutral. Some group I introns are mobile genetic elements due to encoded homing endonuclease genes that function in DNA-based mobility pathways to promote spread to intronless alleles. Group I introns have a limited distribution among bacteria and the current assumption is that they are benign selfish elements, although some introns and homing endonucleases are a source of genetic novelty as they have been co-opted by host genomes to provide regulatory functions. Questions regarding the origin and maintenance of group I introns among the bacteria and phages are also addressed. © 2014 Hausner et al.; licensee BioMed Central Ltd.
CITATION STYLE
Hausner, G., Hafez, M., & Edgell, D. R. (2014, March 10). Bacterial group i introns: Mobile RNA catalysts. Mobile DNA. BioMed Central Ltd. https://doi.org/10.1186/1759-8753-5-8
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