Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations

Abstract

A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 μg mL -1 with molar absorptivity of 2.67 × 10 4 L moL -1 cm -1. The detection limit was found to be 0.18 μg mL -1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.