Enantioselective evans-tishchenko reduction of β-hydroxyketone catalyzed by lithium binaphtholate

Abstract

Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner. © 2011 by the authors; licensee MDPI, Basel, Switzerland.