Introduction. Herpes simplex virus is the most common cause of sporadic viral encephalitis. Cognitive impairments persist in most patients who survive herpes simplex virus-caused encephalitis after undergoing currently available treatments. This is the first report on the development of human cord blood-derived mononuclear cell transplantation as a new treatment intervention to improve the prognosis of sequelae of viral encephalitis. Case presentation. An 11-year-old Han Chinese boy developed sequelae of viral encephalitis with cognitive, mental and motor impairments in the 8 months following routine treatments. Since receiving allogeneic cord blood-derived mononuclear cell transplantation combined with comprehensive rehabilitation therapies 7 years ago, the patient's health has significantly improved and remained stable. Conclusions: Human cord blood-derived mononuclear cell transplantation may be a potential therapeutic strategy for treating the neuropsychiatric and neurobehavioral sequelae of viral encephalitis. © 2013 Yang et al.; licensee BioMed Central Ltd.
CITATION STYLE
Yang, W. Z., Shu, G. J., Zhang, Y., Wu, F., Ye, B. Y., & Hu, X. (2013). Human cord blood-derived mononuclear cell transplantation for viral encephalitis-associated cognitive impairment: A case report. Journal of Medical Case Reports, 7. https://doi.org/10.1186/1752-1947-7-181
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