Regulation of germinal center, B-cell memory, and plasma cell formation by histone modifiers

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Abstract

Understanding the regulation of antibody production and B-cell memory formation and function is core to finding new treatments for B-cell-derived cancers, antibody-mediated autoimmune disorders, and immunodeficiencies. Progression from a small number of antigen-specific B-cells to the production of a large number of antibody-secreting cells is tightly regulated. Although much progress has been made in revealing the transcriptional regulation of B-cell differentiation that occurs during humoral immune responses, there are still many questions that remain unanswered. Recent work on the expression and roles of histone modifiers in lymphocytes has begun to shed light on this additional level of regulation. This review will discuss the recent advancements in understanding how humoral immune responses, in particular germinal centers and memory cells, are modulated by histone modifiers.

Figures

  • FIGURE 1 | Histone modifications that may regulate B-cell differentiation. (A) B-cell differentiation during a T-dependent humoral response. Naïve B-cells that are specific to a foreign pathogen will become activated and receive help from accessory cells. They may become early memory B-cells or extrafollicular plasmablasts, or form a
  • Table 1 | Humoral responses in the absence of EZH2, MOZ, p300 (acetyltransferase activity), or DNMT1 [from Ref. (27–31)].

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APA

Good-Jacobson, K. L. (2014). Regulation of germinal center, B-cell memory, and plasma cell formation by histone modifiers. Frontiers in Immunology. Frontiers Research Foundation. https://doi.org/10.3389/fimmu.2014.00596

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