Ruthenium Tetroxide Oxidation of 3,4-Dihydroisoquinolin-l(2H)-ones: An Efficient Synthesis of Isoquinoline-1,3,4(2H)-triones

Abstract

Ruthenium tetroxide (RuO4) oxidation of 3,4-dihydroisoquinolin-l(2H)-ones produced the corresponding isoquinoline-1,3,4(2H)-triones in good yields. In the cases of N-alkyl derivatives having two oxidation sites adjacent to the nitrogen atom, regioselective endocyclic oxidation was observed. © 1989, The Pharmaceutical Society of Japan. All rights reserved.