Chiral β-Lactam Synthesis through the Enantioselective Reduction of Iminocyclobutenones and the Thermal Rearrangement of Aminocyclobutenones

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Abstract

Chiral β-lactam synthesis was achieved through the enantioselective reduction of iminocyclobutenones catalyzed by a chiral phosphoric acid and the subsequent thermal rearrangement of chiral aminocyclobutenones in the presence of appropriate amines. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Hachiya, I., Ito, A., & Shimizu, M. (2014). Chiral β-Lactam Synthesis through the Enantioselective Reduction of Iminocyclobutenones and the Thermal Rearrangement of Aminocyclobutenones. Asian Journal of Organic Chemistry, 3(5), 614–618. https://doi.org/10.1002/ajoc.201402005

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