Medical treatment of hemangiomas

Abstract

Cytotoxic drugs are a valuable option for the treatment of hemangiomas that interfere with normal functions (vision, breathing, eating, voiding or stooling), result in serious disfigurement, or give rise to ulceration, bleeding, infection, pain, heart and liver failure. Corticosteroids administered systemically are considered first line medical therapy for proliferating hemangiomas. If resistance to corticosteroid treatment is observed or when visceral involvement is present, other cytotoxic drugs such as vincristine or cyclophosphamide can be used. Interferon is effective and was prescribed until recently. However, because of severe neurological toxicity it is increasingly omitted. Here, we summarize the mode of action and side effects as well as the current experience with these drugs used systemically or intra-lesionally. © 2009 Springer-Verlag Milan.