Kinetic profile of silver and zinc oxide nanoparticles by intraperitoneal injection in mice, a comparative study

Abstract

To investigate the kinetic profile (Absorption, distribution, and excretion) of intraperitoneal injected Ag NPs (24.52 nm) and ZnO NPs (25.16 nm) in Albino mice, a single dose of the two kinds of NPs (100 mg/kg) were used for comparison. Kinetic profile in blood clarified shorter time (T max) were spend by ZnO NPs to be absorbed compared with longer one recorded by Ag NPs as their smaller volume of distribution (Vd) to confirm their higher concentration (C max) with 95 g/ml compared with Ag NPs which stands on 57.5 g/ml, also Ag NPs needs longer time of elimination to their half values (t1/2 Elem.) in blood with lower clearance rate (CL) compared with ZnO NPs. This study discussed the distribution profile in different organs over time and pointed a considerable Ag and Zn concentrations specially in liver, spleen, intestine and kidney, also an important levels recorded in lung, heart, testes and brain. Ag and ZnO NPs excretion manner noted a significant percentage of excretion via feces with 33 % and 83%for Ag NPs and ZnO NPs respectively compared with small percentage recorded with urine.