IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease

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Abstract

In the patients with neurological autoimmune diseases such as anti-IgLON5 disease, insomnia symptoms are very common. Clinical diagnosis of the anti-IgLON5 disease is usually made when neurodegenerative processes have occurred. To find the early signs of anti-IgLON5 disease, we evaluate the presence of IgLON5 autoantibodies in the serum of patients with chronic insomnia disease. Based on video-polysomnography, 22 individuals with isolated chronic insomnia disease were found. A control group of 22 healthy people was chosen using the Pittsburgh Sleep Quality Index (PSQI). An indirect immunofluorescence cell-based test of serum anti-IgLON5 antibodies was used to investigate IgLON5 autoimmunity. Anti-IgLON5 antibodies were detected in the serum of four of these patients with the titer of 1/10. The presence of IgLON5 autoantibodies in some patients with chronic insomnia disease can be considered a causing factor of insomnia which can be effective in more specific treatments of these patients. Moreover, the recognition of anti-IgLON5 disease in the early stages and before the progression of tauopathies can be useful in effective and timely treatment.

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APA

Aghelan, Z., Karima, S., Ghadami, M. R., Khazaie, H., Bahrehmand, F., Vaisi-Raygani, A., … Khodarahmi, R. (2022). IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease. Clinical and Experimental Immunology, 207(2), 237–240. https://doi.org/10.1093/cei/uxab017

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