A dietary and behavioural programme for the treatment of obesity. A 4-year clinical trial and a long-term posttreatment follow-up

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Abstract

Objectives. To evaluate weight loss maintenance after 4 years of nonpharmacological, nonsurgical obesity treatment, including a very low calorie diet (VLCD), diet and behavioural support. Furthermore, to assess weight development amongst completers and noncompleters beyond the active 4-year treatment period. Design. Clinical trial. Setting. Two Swedish county hospitals. Subjects. A total of 113 patients were randomized to a 2-year treatment programme with or without an initial VLCD period. The 87 patients who completed the 2-year programme were offered the chance to continue a support programme for another 2 years. A total of 55 patients completed the entire 4-year programme. Interventions. All the patients took part in a comprehensive support programme, including a hypocaloric diet and behavioural support, either as single treatment (non-VLCD group) or following the VLCD period (VLCD group). Results. Significant 4-year weight losses were found in both groups, 7.6 ± 12.2 kg (VLCD group) and 6.3 ± 8.5 kg (non-VLCD group), (P < 0.01, n.s. between groups). The completers (n = 55) had maintained a weight loss of 3.3 ± 10.7 kg (P < 0.05) 8 years after randomization. After 6 years, the noncompleters (n = 58) had gained 3.2 ± 9.7 kg compared with baseline (P < 0.05). The difference in weight change between completers and noncompleters was highly significant (P < 0.01). Conclusions. Highly significant weight losses can be maintained after a 4-year comprehensive treatment programme, including a hypocaloric diet and behavioural support. An initial VLCD period did not significantly affect the long-term weight loss. The posttreatment long-term weight loss was larger amongst completers than amongst patients who did not complete the treatment.

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Lantz, H., Peltonen, M., Ågren, L., & Torgerson, J. S. (2003). A dietary and behavioural programme for the treatment of obesity. A 4-year clinical trial and a long-term posttreatment follow-up. Journal of Internal Medicine, 254(3), 272–279. https://doi.org/10.1046/j.1365-2796.2003.01187.x

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