Comparison of morphine–midazolam versus morphine injection for pain relief in patients with limb fractures - a clinical trial

  • Majidi A
  • Dinpanah H
  • Ashoori S
  • et al.
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Abstract

© 2015 TJTES Background: Pain relief, using opiates as a primary choice, is an important part of treating limb fractures. Yet, in order to reduce opiate consumption, other combinations have been introduced. This study aimed to compare pain reduction by a combination of morphine–midazolam with morphine injection in patients with limb fractures.Methods: A randomized double-blind study of patients with upper or lower extremity fractures was conducted. Patients’ response to treatment with either morphine-midazolam solution or morphine at 15, 30, 45, 60, 120, and 180 minutes were assessed. The Kaplan-Meier curves and generalized estimating equations were examined to evaluate the success of treatment.Results: A total of seventy-two patients aged 18-60 (80.6% male; mean age: 35±17.9 years) were included. At 15, 30, 45, and 60 minutes, successful pain control was seen in 8.83 22.2%, 33.3% and 63.9% of the patients in the morphine group, and 11.1%, 27.7%, 44.4% and 63.8% in the midazolam-morphine group. By the third hour, pain-control was achieved in all patients receiving morphine while pain persisted in one patient receiving morphine-midazolam. Log-rank test showed no signifcant diference between the two groups (p=0.55).Conclusion: Our findings revealed that adding midazolam to morphine did not improve its pain-relief profle.

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APA

Majidi, A., Dinpanah, H., Ashoori, S., Motamed, H., & Tabatabaey, A. (2015). Comparison of morphine–midazolam versus morphine injection for pain relief in patients with limb fractures - a clinical trial. Turkish Journal of Trauma and Emergency Surgery, 21(1), 22–26. https://doi.org/10.5505/tjtes.2015.64494

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