Pharmacological effects of butoxybenzyl hyoscyamine bromide on the motility and secretion of the gastro-intestinal tracts in animals

Abstract

Effects of butoxybenzyl hyoscyamine bromide (BHB) on gastro-intestnal motility and secretion, salivary secretion and pupilis in animals were investigated. BHB inhibited the contraction of nictitating membrane during stimulation of cervical sympathetic preganglionic fiber in the dog. BHB inhibited spontaneous motility, motor activity elicited by bethanechol and the contraction during vagal stimulation in the gastro-intestinal tract of dogs, and also propulsion of charcoal meal in the intestine of mice. BHB reduced the basal or bethanechol stimulated acid secretion in rats and feeding or bethanechol stimulated acid secretion in Heidenhein pouch dogs, but not tetragastrin stimulated acid secretion in rats. BHB did not exhibit the inhibitory effect on the pancreatic and biliary serection in rats. BHB prevented the ulcer formation in the pylorus ligated or stress rats. BHB inhibited the chorda tympani nerve stimulated salivary secretion in dogs and the duration of this effect of BHB was shorter than that of inhibitory effects on gastro-intestinal motor activity. Mydriasis was observed in dogs and mice at large doses of BHB. © 1973, The Japanese Pharmacological Society. All rights reserved.