Prevalence of vitamin D deficiency in patients with spinal cord injury at admission: A single-centred study in the UK

Abstract

Vitamin D deficiency is prevalent in patients with chronic spinal cord injury (SCI) and has been implicated as an aetiologic factor of osteoporosis and various skeletal and extra-skeletal issues in SCI patients. Few data were available regarding vitamin D status in patients with acute SCI or immediately assessed at hospital admission. This retrospective cross-sectional study evaluated vitamin D status in SCI patients at admission to a UK SCI centre in January-December 2017. A total of 196 eligible patients with serum 25(OH)D concentration records at admission were recruited. The results found that 24 % were vitamin D deficient (serum 25(OH)D < 25 nmol/l), 57 % of the patients had serum 25(OH)D < 50 nmol/l. The male patients, patients admitted in the winter-spring time (December-May), and patients with serum sodium < 135 mmol/l or with non-traumatic causes had a significant higher prevalence of vitamin D deficiency than their counterparts (28 % males v. 11·8 % females, P = 0·02; 30·2 % in winter-spring v. 12·9 % in summer-autumn, P = 0·007; 32·1 % non-traumatic v. 17·6 % traumatic SCI, P = 0·03; 38·9 % low serum sodium v. 18·8 % normal serum sodium, P = 0·010). There was a significant inverse association of serum 25(OH)D concentration with body mass index (BMI) (r = -0·311, P = 0·002), serum total cholesterol (r = -0·168, P = 0·04) and creatinine concentrations (r = -0·162, P = 0·02) that were also significant predictors of serum 25(OH)D concentration. Strategies for systematic screening and efficacy of vitamin D supplementation in SCI patients need to be implemented and further investigated to prevent the vitamin D deficiency-related chronic complications.