The immunopharmacological activities of bacterial cell walls and muramyl peptides were collected in table form with a comprehensive literature. The past and present studies emphasizing the host-defense enhancing activities of muramyl peptides for antitumor immunotherapy were surveyed along three possible approaches: 1) the nonspecific enhancement of natural defense ability of host against tumor cells themselves; 2) the enhancement of nonspecific resistance of host to microbial infections which are frequently encountered and difficult to treat in the advanced stage of tumor patients; and 3) the stimulation of immunity against tumor-specific or tumor-associated immunogens. Finally, the prospects of successful antitumor immunotherapy with muramyl peptides and their derivatives was discussed.
CITATION STYLE
Kotani, S., Azuma, I., Takada, H., Tsujimoto, M., & Yamamura, Y. (1983). Muramyl dipeptides: prospect for cancer treatments and immunostimulation. Advances in Experimental Medicine and Biology, 166, 117–158. https://doi.org/10.1007/978-1-4757-1410-4_12
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