IL-17 in systemic lupus erythematosus

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Abstract

IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3 + CD4- CD8- (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells. © 2010 J. C. Crispín and G. C. Tsokos.

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Tsokos, G. C., & Crispín, J. C. (2010). IL-17 in systemic lupus erythematosus. Journal of Biomedicine and Biotechnology. https://doi.org/10.1155/2010/943254

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