Use of silica-gold core shell structured nanoparticles for targeted drug delivery system

Abstract

Drug targeting, using Silica-Gold core carrier particles loaded with antibiotic drugs is an emerging and significant method of disease treatment. Silica core particles were synthesized by Stober's method and it was functionalized with amine groups. The monodispersed Gold particles were prepared by conventional citrate reduction method. Both functionalized Silica and monodispersed Gold nanoparticles were combined and Silica-Gold core nanoshells was prepared in the range of 60-110nm. The morphology, elemental composition of the core nanoshell was characterized by UV-Visible spectroscopy, FT-IR spectroscopy, Scanning Electron Microscope (SEM), Energy Diffusive Spectroscopy (EDX) and X-ray Diffraction analysis. The antibiotic Gentamycin was loaded onto these Silica-Gold core nanoshell carriers and the drug release profile was observed. © 2011 Amirthalingam T, et al.