Influence of uvulopalatopharyngoplasty on serum uric acid level in obstructive sleep apnea patients

Abstract

Background: The objective of this study was to determine whether there is an association between successful uvulopalatopharyngoplasty (UPPP) and serum uric acid in patients with obstructive sleep apnea (OSA), and identify the risk markers for successful UPPP in OSA patients. Methods: We performed a prospective cohort study of 73 adult patients with OSA who underwent surgery (nasal or UPPP) at a major, urban, academic hospital in Huaian from 2011 to 2014 who had preoperative and postoperative clinical and laboratory profiles. Demographic, clinical, laboratory, and PSG parameters were carefully recorded. Logistic regression was used for the multivariate analysis of independent risk factors. Results: Changes of uric acid (UA), changes of C-reactive protein (CRP), changes of triglyceride, changes of high density lipoprotein before and after UPPP were significantly higher in OSA patients with successful UPPP than in those with unsuccessful UPPP (p<0.05). Among these patients, multiple logistic analyses indicated the independent risk factors for successful UPPP in the OSA subjects included changes of UA and CRP before and after UPPP. The diagnosis analysis showed that changes of UA and CRP before and after UPPP had a significant ability to reflect UPPP success in the OSA patients. Conclusions: The novel finding of this study is that the successful UPPP in OSA patients is strongly related to changes of serum UA level, CRP before and after operation. These results might be helpful for providing valuable information to reflect the effect of UPPP operation, regardless of UA and CRP before operation.