Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma

9Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Pseudotumours are well recognised as a complication of metal-on-metal hip arthroplasties and are thought to develop on the basis of an innate and adaptive immune response to cobalt-chrome (Co-Cr) wear particles. We report a case of a large pseudotumour that developed following a knee endoprosthetic replacement (EPR) undertaken for Ewing sarcoma. The lesion contained necrotic and degenerate connective tissue in which there were numerous scattered metal wear-containing macrophages, eosinophil polymorphs, lymphocytes, plasma cells and aseptic lymphocyte-dominated vascular-associated lesion-like lymphoid aggregates. Metal ion levels were elevated. No evidence of infection or tumour was noted and it was concluded that the lesion was most likely an inflammatory pseudotumour developing on the basis of an innate and adaptive immune response to components of Co-Cr metal wear derived from the knee EPR.

Cite

CITATION STYLE

APA

Craig, R., Vlychou, M., McCarthy, C. L., Gibbons, C. L. M. H., & Athanasou, N. A. (2017). Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma. Skeletal Radiology, 46(7), 967–974. https://doi.org/10.1007/s00256-017-2610-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free