Drug delivery across the blood-brain barrier (BBB) is a major obstacle for the development of effective treatments of many central nervous system disorders. Sophisticated cell culture models of the BBB have helped us to identify, characterize, and validate a novel targeted drug delivery technology, designated 2B-Trans™, for the receptor-mediated uptake and transport of drugs across the BBB. This paper describes in great detail how such a BBB cell culture model should be prepared and handled, and applied for the use of targeted drug delivery across the BBB. © 2008 Humana Press.
CITATION STYLE
Gaillard, P. J., & De Boer, A. G. (2008). 2B-transTM technology: Targeted drug delivery across the blood-brain barrier. Methods in Molecular Biology, 437, 161–175. https://doi.org/10.1007/978-1-59745-210-6_8
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