The experience of external radiotherapy can only to a limited extent be used to understand therapeutic effects of radionuclide therapy. A major difference is that the dose-rate at radionuclide therapy is at least two orders of magnitude lower. Part of this chapter deals with estimates of the necessary dose-rate and exposure time in combination in order to deliver therapeutic effects to tumour cells. It is proposed that combinations of about 0.1-0.2 Gy/h for several days or about 1 Gy/h for at least 1 day is necessary. Such dose-rates can be achieved with the help of cross fire radiation. Effects of radionuclide therapy in terms of apoptosis, cell-cycle blocks and hyperradiosensitivity are also discussed. © 2008 Springer Science+Business Media B.V.
CITATION STYLE
Carlsson, J. (2008). Effects of low dose-rate radiation on cellular survival. In Targeted Radionuclide Tumor Therapy: Biological Aspects (pp. 295–310). Springer Netherlands. https://doi.org/10.1007/978-1-4020-8696-0_16
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