Estrogen (E) plays a pivotal regulatory role in the control of cell proliferation in the normal breast and breast cancer (BC). To identify genes with likely roles in proliferation control that are regulated by E and its downstream target c-myc, we compared transcript profiles of antiestrogens- arrested cells stimulated to reinitiate cell cycle progression by E treatment or c-myc induction. Approximately 2/3 of the probe sets significantly regulated by E (adjusted p < 0.01) increased in expression. Half of the E-regulated probe sets were also regulated by c-myc. Genes involved in cell growth, cell proliferation, and cell survival were over-represented in the E-regulated geneset. Analysis of selected candidates has identified a nucleolar protein whose expression is correlated with c-myc expression in BC cell lines. These data indicate that a significant component of E-induced mitogenesis is mediated by c-myc and that selected c-myc target genes may be surrogate markers of c-myc expression in BC. © 2008 Springer Science+Business Media, LLC.
CITATION STYLE
Musgrove, E. A., Sergio, C. M., Anderson, L. R., Inman, C. K., McNeil, C. M., Alles, M. C., … Sutherland, R. L. (2008). Identification of downstream targets of estrogen and c-myc in breast cancer cells. In Advances in Experimental Medicine and Biology (Vol. 617, pp. 445–451). https://doi.org/10.1007/978-0-387-69080-3_43
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