Polymyxin toxicity remains a significant concern that limits the clinical utility of this class of antibacterials for patient care. The most notable adverse event is the dose- and treatment-limiting nephrotoxicity that occurs in roughly 30–60% of patients receiving a systemic polymyxin. This chapter focuses on this adverse event with a detailed assessment of the incidence of, and risk factors for, polymyxin-associated nephrotoxicity. In particular, the text focuses on the impact of dose, serum concentrations, and polymyxin selection on nephrotoxicity. Additionally, less common, but clinically important adverse events are discussed.
CITATION STYLE
Pogue, J. M., & Tam, V. H. (2019). Toxicity in Patients. In Advances in Experimental Medicine and Biology (Vol. 1145, pp. 289–304). Springer New York LLC. https://doi.org/10.1007/978-3-030-16373-0_17
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