Hypolipidemic activity of Kadukkai Chooranam (Terminalia chebula) in Triton WR - 1339 induced hyperlipidemic rats.

Abstract

A Ab bs st tr ra ac ct t: : Aim: To validate the hypolipidemic efficacy of Kadukkai Choornam (Terminalia chebula) in Triton WR – 1339 induced hyperlipidemic rats.Methodology: Fresh fruits of Terminalia chebula (Kadukkai) were collected and identified by the botanist. After authentication, pericarp was separated from the fruit and was used for the preparation of Kadukkai Choornam (powder form of pericarp of Terminalia chebula) as per the classical Siddha literature. This powder form was tested against Triton induced hyperlipidemic rats. The experimental procedure was carried out for 7 days. Rats are provided normal diet and water ad libitum. Two doses of 250 mg/kg and 500 mg/kg were selected for experimental study. Statistical analysis of lipid profile, liver lipid profile, body weight, organ weight and atherogenic index were done and compared with triton control group, standard group and normal control group. Results: There was no significant increase in the weight of drug treated groups and standard group rats. Kadukkai chooranam at the dose of 250 mg and 500 mg/kg significantly reduced the serum total cholesterol, triglycerides, LDL and VLDL and increases the high density lipoprotein when compared to the triton control group. This observation indicated that Kadukkai Choornam has hypolipidemic effect on both doses. Higher dose reduced the lipid profile more significantly than lower dose level which indicated the dose dependent activity of Kadukkai Choornam. Conclusion: It can be concluded that the Siddha classical preparation of Kadukkai Chooranam was effective in reducing the total cholesterol, triglycerides, LDL, VLDL and increases the high density lipoprotein level successfully and proved the traditional claim of hypolipidemic activity.